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  • Title: The significance of urinary N-acetyl-beta-D-glucosaminidase for predicting early stage diabetic nephropathy.
    Author: Kato H, Takashima T, Kishikawa H, Emura S, Ohmori K.
    Journal: Int J Clin Pract; 1997; 51(8):489-90. PubMed ID: 9536599.
    Abstract:
    We studied urinary N-acetyl-beta-D-glucosaminidase (NAG) in the early stage of diabetic nephropathy in 27 non-insulin-dependent diabetes mellitus (NIDDM) patients with a microalbumin level below 20 mg on 24-hour urine sample. Microalbumin and NAG excretion were measured in 24-hour urine samples collected on three separate occasions within seven days of admission. Creatinine clearance was determined simultaneously. There was a significant negative correlation between the creatinine clearance and 24-hour urinary NAG (r = -0.38, p < 0.05). Elevation of urinary NAG may indicate decreased renal function during early stage NIDDM nephropathy.
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