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  • Title: Late components of the event-related potentials and their topography in Parkinson's disease.
    Author: Lagopoulos J, Clouston P, Barhamali H, Gordon E, Li WM, Lesley J, Morris JG.
    Journal: Mov Disord; 1998 Mar; 13(2):262-7. PubMed ID: 9539339.
    Abstract:
    Late components of the event-related potential (ERP; N100, P200, N200, and P300) were elicited using an auditory oddball paradigm (with a button-press response to target stimuli) in 15 Parkinson's disease (PD) patients and 50 normal control subjects. Compared with control subjects, PD subjects showed a significant decrease in N200 amplitude. Between-group topographical differences in N200 amplitude were evident at central (C3, Cz, C4) and temporal (T5, T3, T4, T6) regions. The results may reflect a deficit in response selection in PD possibly resulting from a dysfunction associated with the abnormalities in the central and temporal regions found to have a decreased N200 amplitude compared with normal control subjects in this study.
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