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  • Title: The diagnostic utility of c-ANCA in Wegener's granulomatosis.
    Author: Langford CA.
    Journal: Cleve Clin J Med; 1998 Mar; 65(3):135-40. PubMed ID: 9540246.
    Abstract:
    Anti-neutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) have been found to have a high degree of sensitivity and specificity for Wegener's granulomatosis. Nevertheless, despite the attraction of using this autoantibody as a diagnostic test, in almost all instances it should not be used in place of a biopsy to diagnose Wegener's granulomatosis.
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