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  • Title: HLA-A, -B, -DR and -DQ antigens in black patients with infective endocarditis.
    Author: Maharaj B, Khedun SM, Hammond MG, van der Byl K.
    Journal: S Afr Med J; 1998 Feb; 88 Suppl 1():C10-2. PubMed ID: 9542489.
    Abstract:
    In order to determine if genetically determined immune response factors could play a role in the pathogenesis of infective endocarditis in black patients, we performed HLA-A and HLA-B typing in 38 patients with this disease and HLA-DR and HLA-DQ typing in 33 and 27 of these individuals, respectively. HLA typing was also carried out in a control group of normal black adults. The HLA typing was done by means of a standard microlymphocytotoxicity test. No difference in HLA-A, HLA-B, HLA-DR and HLA-DQ antigen frequencies between patients and controls were noted. This study did not provide any evidence that genetic factors could contribute to a disposition to infective endocarditis.
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