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  • Title: Emergence of antimicrobial resistance in community-acquired pulmonary pathogens.
    Author: Cunha BA, Shea KW.
    Journal: Semin Respir Infect; 1998 Mar; 13(1):43-53. PubMed ID: 9543475.
    Abstract:
    Antibiotic resistance to the common respiratory tract pathogens is increasing worldwide. Penicillin-resistant pneumococci are of particular concern. Most strains of penicillin-resistant Streptococcus pneumoniae have intermediate resistance to penicillin, and highly resistant strains are rare at present. Careful selection of antibiotics with low resistance potential and excellent activity against highly penicillin-resistant pneumococci (ie, cefotaxime, ceftriaxone, cefepime, cefprozil, doxycycline, levofloxacin, sparfloxacin, and meropenem) is the best current strategy to delay or increase the emergence of highly penicillin-resistant strains of S pneumoniae.
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