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  • Title: Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin.
    Author: Kim-Shapiro DB, King SB, Bonifant CL, Kolibash CP, Ballas SK.
    Journal: Biochim Biophys Acta; 1998 Mar 12; 1380(1):64-74. PubMed ID: 9545536.
    Abstract:
    Hydroxyurea has been mixed with hemoglobin S and the reaction was studied using electronic absorption spectroscopy as a function of time and wavelength. The rate of conversion of oxyhemoglobin S to other species was determined and the nature of the reaction products was studied. We also report the formation of methemoglobin (and other reaction products) when deoxyhemoglobin S is combined with hydroxyurea. The probable increase in the formation of methemoglobin, and other potential reaction products such as nitric oxide-hemoglobin, in patients with sickle cell anemia who are taking hydroxyurea as a therapeutic drug is discussed in terms of the pathophysiology of the disease. It is proposed that methemoglobin and possibly nitric oxide-hemoglobin formation may partially explain beneficial effects observed in these patients before their levels of fetal hemoglobin have increased.
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