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  • Title: A prospective clinical trial comparing metrizamide and iohexol for equine myelography.
    Author: Widmer WR, Blevins WE, Jakovljevic S, Levy M, Teclaw RF, Han CM, Hurd CD.
    Journal: Vet Radiol Ultrasound; 1998; 39(2):106-9. PubMed ID: 9548136.
    Abstract:
    A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via cerebellomedullary puncture. Each horse was evaluated postmyelographically for adverse effects. Myelographic quality was assessed by a numerical scoring method. Adverse effects were observed more frequently with metrizamide (21) compared with iohexol (6) myelography (p < 0.05). Seizures, intensification of preexisting neurologic signs and prolonged anesthetic recovery were the most common complications after myelography. There was no difference in myelographic quality (p > 0.05). We conclude that iohexol is safer than metrizamide for equine myelography and that quality myelograms can be obtained with either contrast medium.
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