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Title: Primary Sjögren's syndrome complicated by sarcoidosis. Author: Miyata M, Takase Y, Kobayashi H, Kokubun M, Yoshimura A, Katsuura Y, Nishimaki T, Kasukawa R. Journal: Intern Med; 1998 Feb; 37(2):174-8. PubMed ID: 9550600. Abstract: Sjögren's syndrome and sarcoidosis share several common features, such as keratoconjunctivitis sicca, swelling of parotid glands, lung involvement, cutaneous anergy, T cell-mediated immunodeficiency, an increased CD4+/CD8+ lymphocyte ratio, and association with the human leucocyte antigen (HLA)-B 8 and DR 3 haplotypes. However, only five patients with primary Sjögren's syndrome and sarcoidosis have been previously reported in the English language literature. The rare case of a 49-year-old Japanese woman with primary Sjögren's syndrome complicated by sarcoidosis is described. The serum angiotensin-converting enzyme level was increased, and histological examination of lung and skin biopsies revealed noncaseating granulomas, indicating that her primary Sjögren's syndrome was complicated by sarcoidosis.[Abstract] [Full Text] [Related] [New Search]