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  • Title: Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
    Author: Barford D, Neel BG.
    Journal: Structure; 1998 Mar 15; 6(3):249-54. PubMed ID: 9551546.
    Abstract:
    The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains. Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.
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