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  • Title: Calcipotriol improves the efficacy of cyclosporine in the treatment of psoriasis vulgaris.
    Author: Kokelj F, Torsello P, Plozzer C.
    Journal: J Eur Acad Dermatol Venereol; 1998 Mar; 10(2):143-6. PubMed ID: 9553911.
    Abstract:
    OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of the association of calcipotriol ointment (50 micrograms/g) plus cyclosporine versus cyclosporine alone in the treatment of moderate psoriasis (mean PASI: 13). METHODS: Twenty patients were enrolled in this right-left open study. All the patients admitted were treated with cylosporine at an initial dose of 4.5 mg/kg/day; in case of clinical improvement this dosage was reduced by 0.5 mg/kg/day every 15 days. In each patient we chose two similar, symmetrical lesions and calcipotriol ointment was applied only on the right lesion, twice a day, until the healing of the lesion or for 1 month. Patients were checked at baseline and every 15 days. RESULTS: Eighteen patients completed the study and 17 of the 18 presented more evident improvement on the side treated with combined therapy, while only one patient showed a better result on the side treated with cyclosporine alone. A significant difference of the total score was already present after 15 days of therapy and was confirmed at the following check-ups. CONCLUSIONS: These results underline the usefulness of the association of calcipotriol and cyclosporine in order to decrease the total dosage of cyclosporine.
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