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  • Title: Corrosion behavior of copper in a copper bearing intrauterine device in the presence of indomethacin.
    Author: Xue H, Xu N, Zhang C.
    Journal: Contraception; 1998 Jan; 57(1):49-53. PubMed ID: 9554251.
    Abstract:
    As an improvement to the use of the copper bearing intrauterine device, indomethacin has been introduced to reduce the incidence of bleeding after insertion of the device. The effects of indomethacin on copper corrosion were studied in vitro in simulated uterine fluid. Electrochemical polarization resistance measurements indicated that indomethacin powder slightly increased the corrosion rate of copper if pH of the fluid was not under control and it did not change the corrosion rate if pH was adjusted daily to maintain some constancy. The experimental results for medication by indomethacin-releasing Silastic were basically the same as those with powdered indomethacin. X-ray diffraction showed that only cuprous oxide was formed on the copper substrated surface and that indomethacin did not affect the corrosion products. As scanning electron microscopy demonstrated, however, in the presence of indomethacin the oxide particles formed were found to be more coarse and dense than in the absence of indomethacin. The effects of indomethacin--a prostaglandin synthesis inhibitor introduced to copper-bearing IUDs to reduce the incidence of postinsertion bleeding--on copper corrosion were investigated in vitro in simulated uterine fluid by Chinese researchers. Indomethacin was introduced to the solution either in various amounts of powdered preparation or in indomethacin-releasing Silastic of different contents. Electrochemical polarization resistance measurements indicated that indomethacin powder slightly increased the copper corrosion rate if the pH of the fluid was not under control, but did not affect corrosion when the pH was adjusted daily to maintain some constancy. Indomethacin-releasing Silastic produced similar effects. X-ray diffraction revealed that, after immersion in the simulated uterine fluid for 7 days, only cuprous oxide was formed on the copper substrate surface, regardless of the presence of indomethacin. Scanning electron microscopy showed that the oxide particles formed were more course and dense in the presence of indomethacin, however. Although these findings suggest that indomethacin does not affect the general corrosion rate of copper, further research is required to verify reduced ion generation.
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