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  • Title: Effect of alpha-tocopherol status on alpha-tocopherol transfer protein expression and its messenger RNA level in rat liver.
    Author: Kim HS, Arai H, Arita M, Sato Y, Ogihara T, Inoue K, Mino M, Tamai H.
    Journal: Free Radic Res; 1998 Jan; 28(1):87-92. PubMed ID: 9554836.
    Abstract:
    Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of alpha-tocopherol transfer protein (alphaTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the alphaTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of alphaTTP can be regulated by the vitamin E nutritional status.
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