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  • Title: A distinctive class of integron in the Vibrio cholerae genome.
    Author: Mazel D, Dychinco B, Webb VA, Davies J.
    Journal: Science; 1998 Apr 24; 280(5363):605-8. PubMed ID: 9554855.
    Abstract:
    The ability of bacteria to acquire and disseminate heterologous genes has been a major factor in the development of multiple drug resistance. A gene, intI4, was identified that encodes a previously unknown integrase that is associated with a "gene-VCR" organization (VCRs are Vibrio cholerae repeated sequences), similar to that of the well-characterized antibiotic resistance integrons. The similarity was confirmed by IntI1-mediated recombination of a gene-VCR cassette into a class 1 integron. VCR cassettes are found in a number of Vibrio species including a strain of V. metschnikovii isolated in 1888, suggesting that this mechanism of heterologous gene acquisition predated the antibiotic era.
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