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  • Title: [Combination therapy in early rheumatoid arthritis: the COBRA study].
    Author: Boers M, Verhoeven AC, van der Linden S.
    Journal: Ned Tijdschr Geneeskd; 1997 Dec 13; 141(50):2428-32. PubMed ID: 9555126.
    Abstract:
    The scheme 'Combination therapy in rheumatoid arthritis' (COBRA) in early rheumatoid arthritis (RA) involves administration of not only sulfasalazine but also prednisolone and methotrexate during the first six months. The trial showed that the COBRA scheme over a period of 1.5 years was superior to sulfasalazine alone: less disease activity in the major part of the year of treatment, less articular damage on radiographs, fewer side effects and equal or reduced costs. An 'aggressive' treatment in patients with early RA is indicated, with (re)assessment of the use of corticosteroids.
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