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Title: Prostatic fluid and tissue concentrations of ampicillin after administration of hetacillin ester (BL-P1761). Author: Kjaer TB, Madsen PO. Journal: Invest Urol; 1976 Jul; 14(1):57-9. PubMed ID: 955850. Abstract: Ampicillin concentrations in prostatic fluid and tissue were studied in dogs after constant intravenous infusion of ampicillin (three dogs) and a lipid-soluble methoxymethyl ester of hetacillin, BL-P1761 (six dogs). Prostatic fluid ampicillin concentrations as determined by bioassay were found to be approximately 15 times higher after administration of hetacillin than after a similar amount of ampicillin. The prostatic fluid concentrations after hetacillin ester administration were approximately one-half of the simultaneous plasma concentrations. This hetacillin ester is thus the first penicillin compound shown to be penetrating the blood-prostatic fluid barrier, resulting in clinically relevant prostatic fluid concentrations.[Abstract] [Full Text] [Related] [New Search]