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  • Title: Histopathological evaluation of the tissue reactions to Endo-Fill root canal sealant and filling material in rats.
    Author: Görduysus MO, Etikan I, Gököz A.
    Journal: J Endod; 1998 Mar; 24(3):194-6. PubMed ID: 9558586.
    Abstract:
    In this in vivo study, the tissue reactions to silicone-based Endo-Fill root canal filling material were histopathologically evaluated. The reaction of rat connective tissue to polyethylene tube implants that were filled with Endo-Fill were evaluated at 2 days, at 1, 2, 4, and 8 weeks. Four tube were implanted in each rat subcutaneously, and a total of 15 rats were used. Rats were killed, and the specimens were examined under the light microscope (x115 and x230). At the end of 8 wk, a thin fibrous wall with an almost completed advanced healing process was observed around the implant material, but no capsule formation or any inflammatory infiltration was seen.
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