These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.
    Author: Taniguchi N, Ikeda Y.
    Journal: Adv Enzymol Relat Areas Mol Biol; 1998; 72():239-78. PubMed ID: 9559055.
    Abstract:
    The gamma-glutamyl transpeptidases are key enzymes in the so-called gamma-glutamyl cycle involving glutathione synthesis, the recovery of its constituents, and in the transport of amino acids. This membrane-bound ectoenzyme thus serves to regulate glutathione synthesis. This chapter deals with the active site chemistry of gamma-glutamyl transpeptidase, including the role of side-chain groups on the light subunit as well as several serine residues in the catalytic process. Also considered are genomic studies indicating (a) the presence of a single gene in mouse and rat; (b) the occurrence of multiple genes in humans; (c) the involvement of multiple promoters for gene expression; and (d) how these multiple promoters may play a role in the tissue-specific expression of gamma-glutamyl transpeptidases.
    [Abstract] [Full Text] [Related] [New Search]