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  • Title: Is topical tretinoin safe during the first trimester?
    Author: Shapiro L, Pastuszak A, Curto G, Koren G.
    Journal: Can Fam Physician; 1998 Mar; 44():495-8. PubMed ID: 9559187.
    Abstract:
    QUESTIONOne of my patients conceived while using a topical tretinoin preparation for acne. I know this drug is related to Accutane, which is teratogenic. How should I advise her?ANSWERAvailable evidence suggests that topical tretinoin does not increase teratogenic risk in humans.
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