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  • Title: [Intestinal mucosa in rats with iron deficiency anemia].
    Author: Salazar De Sousa J, Pinheiro JB, Garcia MF, Pais MV, Nunes V.
    Journal: Helv Paediatr Acta; 1976 Aug; 31(2):167-71. PubMed ID: 955940.
    Abstract:
    Eighteen albino rats at the age of 15 days were separated in 2 groups of 9 and fed cow's milk exclusively. The milk supplied to the control rats (group I) was supplemented with iron and copper. The months later, the rats were scarificed. The animals of group II were severely anaemic. In each rat, a histological examination of gastric (in group II, only in 2 rats) and jejunal mucosa as well as measurements of total thickness, villous height, epithelial cell height and mitotic index were made. Histology was normal in all the rats. Measurements gave similar results in both groups except for the epithelial cell height which was significantly higher in anaemic rats than in controls. The authors take issue with the methodology followed in previous studies concerning iron-deficient children and suggest that the causal relation between iron deficiency and structural changes of intestinal mucosa in children has not yet been proven.
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