These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain.
    Author: Kowaltowski AJ, Costa AD, Vercesi AE.
    Journal: FEBS Lett; 1998 Mar 27; 425(2):213-6. PubMed ID: 9559650.
    Abstract:
    A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.
    [Abstract] [Full Text] [Related] [New Search]