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  • Title: Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones.
    Author: Zhao X, Wang JY, Xu C, Dong Y, Zhou J, Domagala J, Drlica K.
    Journal: Antimicrob Agents Chemother; 1998 Apr; 42(4):956-8. PubMed ID: 9559820.
    Abstract:
    C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.
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