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  • Title: Efficacy of LY333328 against experimental methicillin-resistant Staphylococcus aureus endocarditis.
    Author: Kaatz GW, Seo SM, Aeschlimann JR, Houlihan HH, Mercier RC, Rybak MJ.
    Journal: Antimicrob Agents Chemother; 1998 Apr; 42(4):981-3. PubMed ID: 9559828.
    Abstract:
    The in vivo efficacy of LY333328, a new glycopeptide antibiotic, was compared with that of vancomycin by using the rabbit model of left-sided methicillin-resistant Staphylococcus aureus endocarditis. Animals received LY333328 or vancomycin (25 mg/kg of body weight every 24 or 8 h, respectively) for 4 days. These drugs were equally effective in clearing bacteremia and in reducing bacterial counts in vegetations and tissues. We conclude that in this model, LY333328 was microbiologically effective and may be a therapeutic alternative to vancomycin.
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