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  • Title: C-cell adenoma containing variously sized thyroid follicles in a horse.
    Author: Kuwamura M, Shirota A, Yamate J, Kotani T, Ohashi F, Sakuma S.
    Journal: J Vet Med Sci; 1998 Mar; 60(3):387-9. PubMed ID: 9560793.
    Abstract:
    A thyroid gland tumor, showing unusual histology, was identified in a 13-year-old male Andalusian horse. Microscopically, the tumor consisted of neoplastic proliferation of C-cell (parafollicular cell) with cytoplasmic fine granules, containing diffusely distributed, variously sized colloid-containing follicles. Immunohistochemically, the neoplastic C-cell were positive for calcitonin and follicleforming epithelial cells showed a positive reaction for thyroglobulin. Ultrastructurally, membrane-bound secretory granules up to 250 nm in diameter were found in the cytoplasm of the parafollicular cells, whereas the follicular epithelial cells had microvilli, junctional complex, and well-developed endoplasmic reticulum.
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