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  • Title: Progressive pan-colonic fibrosis secondary to oral administration of pancreatic enzymes.
    Author: Moss RL, Musemeche CA, Feddersen RM.
    Journal: Pediatr Surg Int; 1998 Mar; 13(2-3):168-70. PubMed ID: 9563037.
    Abstract:
    Most patients with cystic fibrosis require oral administration of pancreatic enzymes to treat pancreatic insufficiency. Recent use of higher-strength enzyme preparations in large doses has been found to be associated with fibrotic strictures of the colon. We report a case of pancolonic fibrosis due to pancreatic enzyme use.
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