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  • Title: Swelling-activated potassium currents of Ehrlich ascites tumour cells.
    Author: Riquelme G, Sepúlveda FV, Jørgensen F, Pedersen S, Hoffmann EK.
    Journal: Biochim Biophys Acta; 1998 Apr 22; 1371(1):101-6. PubMed ID: 9565660.
    Abstract:
    The K+ and Cl- currents activated by Ca2+-ionophore treatment or by hypotonic cell swelling have been studied in Ehrlich ascites tumour cells by the patch-clamp technique. A charybdotoxin-inhibitable K+ current was activated by increasing intracellular Ca2+ concentration. In contrast, the K+ current activated by cell swelling was insensitive to charybdotoxin as well as to apamin, suggesting that channels different from those sensitive to Ca2+ are responsible for regulatory volume adjustments in these cells. The magnitude of the K+ and Cl- currents activated by hypotonic challenge was markedly temperature-dependent, possibly reflecting the temperature-dependence of enzymes involved in the intracellular signalling of cell volume regulation.
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