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  • Title: Changes in peripheral hormone levels after therapeutic abortion.
    Author: Saunders DM, Kelso IM, Grudzinskas JG, Hughes GJ, Wilson GR.
    Journal: Eur J Obstet Gynecol Reprod Biol; 1978 Feb; 8(1):1-4. PubMed ID: 95666.
    Abstract:
    Plasma levels of progesterone, 17 alpha-OH progesterone, hPL and beta-subunit hCG were measured in a group of women for 24 h after therapeutic abortion. Progesterone, hCG and hPL levels fell more rapidly than 17 alpha-OH progesterone levels. This might suggest that the main site of synthesis of 17 alpha-OH progesterone is probably in the corpus luteum of pregnancy or that the prolonged half-life of hCG maintains the corpus luteum to secrete longer. Human placental lactogen fell dramatically within 4 h but the hCG level was maintained. This difference probably reflects only the differences in half-lives of these hormones. Plasma levels of progesterone, 17 alpha hydroxyprogesterone (OHP), human placental lactogen (hPL), and beta-subunit human chorionic gonadotropin (hCG) were measured in 9 Australian and 10 Scottish therapeutic abortion patients for 24 hours after the procedure. Progesterone levels fell to 50% within 4 hours of termination and were at 15% of preabortion levels at 24 hours in the Scottish group. Among Australian subjects, the progesterone level fell to 26% of the pretermination value by 4 hours and to 6% of this after 24 hours. The mean level of 17 alpha-OHP was 83% of the pretermination value at 4 hours and 63% at 24 hours. There was no significant change in the circulating level of hCG within the 1st 4 hours; at 24 hours, the level was still 43% of the pretermination value. hPL fell drastically, to 14% of the basal level, within the 1st 4 hours and remained at this level for the next 18 hours. Changes at 24 hours were statistically significant for hPL, hCG, and progesterone. Thus, these 3 hormones can be considered reliable indices of outcome in cases of threatened abortion. The finding that 17 alpha-OHP falls more slowly than the other parameters suggests that it is primarily produced by the corpus luteum of pregnancy, or that the prolonged half-life of hCG maintains the corpus luteum to secrete longer.
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