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  • Title: Embryonic implantation in galectin 1/galectin 3 double mutant mice.
    Author: Colnot C, Fowlis D, Ripoche MA, Bouchaert I, Poirier F.
    Journal: Dev Dyn; 1998 Apr; 211(4):306-13. PubMed ID: 9566950.
    Abstract:
    Galectin 1 and galectin 3 are first expressed in the trophectoderm cells of the implanting embryo and have been implicated in the process of implantation. However, we had previously shown that the lack of galectin 1 in galectin 1 null mutant mice is compatible with implantation. In this study, we describe the generation of galectin 3 null mutant mice and show that they are viable and have no overt abnormalities. The importance of galectin 1 and galectin 3 in implantation was assessed by obtaining double mutant mice [gal1 -/-; gal3 -/-]. We find that implantation can still occur in the absence of both galectin 1 and galectin 3. However, we show that galectin 5, a third member of this gene family, is also present in the blastocyst at the time of implantation.
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