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  • Title: Dose-proportional pharmacokinetics of a new 5-lipoxygenase inhibitor, ABT-761, in healthy volunteers.
    Author: Wong SL, Drajesk J, Chang MS, Witt G, Awni WM.
    Journal: Biopharm Drug Dispos; 1998 Apr; 19(3):159-62. PubMed ID: 9569998.
    Abstract:
    ABT-761, a new potent 5-lipoxygenase inhibitor, is under development for the treatment of asthma. The pharmacokinetics and dose proportionality of ABT-761 after single doses (10-160 mg) of ABT-761 in 24 healthy male volunteers were investigated in a double-blind, placebo-controlled study. The compound was well tolerated, with no clinically significant effects on vital sign measurements, hematological parameters, clinical chemistry, urinalysis, or electrocardiogram. The plasma concentration-time profile of ABT-761 indicates that the drug declines in a monoexponential fashion after moderately slow absorption, with a tmax value of approximately 4 h. The terminal elimination t1/2 averaged 15 h, and was dose independent. ABT-761 mean values of Cmax and AUC were linearly related to drug dose. ABT-761 is well tolerated in healthy volunteers and the pharmacokinetics are linear in the single-dose range between 10 and 160 mg.
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