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  • Title: Effect of neurotensin, substance P and morphine sulfate on the secretion of prolactin and growth hormone in the rat.
    Author: Rivier C, Brown M, Vale W.
    Journal: Endocrinology; 1977 Mar; 100(3):751-4. PubMed ID: 95701.
    Abstract:
    Neurotensin (NT), substance P (SP) and morphine sulfate (MS) elevate plasma prolactin and growth hormone levels in both normal or estrogen-progesterone pretreated male rats. By contrast, steroid priming is required for TRF to exhibit PRL-releasing activity. Naloxone, an opiate receptor blocker, reverses the stimulatory effect of MS only. Diphenhydramine, a histamine antagonist, inhibits the response to NT, SP and MS without affecting the response to TRF. These results suggest the involvement of a histaminic step in the action of NT, SP and MS. TRF, NT and SP do not appear to stimulate PRL and GH through activation of an opiate receptor.
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