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  • Title: Abnormal callosal morphology in male adult dyslexics: relationships to handedness and phonological abilities.
    Author: Robichon F, Habib M.
    Journal: Brain Lang; 1998 Mar; 62(1):127-46. PubMed ID: 9570883.
    Abstract:
    The classical notion that developmental dyslexia may somehow relate to impaired communication between hemispheres has not yet received convincing support. Sixteen dyslexic adults and 12 controls received a high resolution brain MRI scan for morphometric study of the corpus callosum. Automatized measurements of callosal area and calculation of indices defining the general morphology of the callosal mid-surface were performed. Each participant received global intelligence and reading achievement evaluation; dyslexics were further proposed specific neuropsychological tests specially designed to explore the mechanisms of reading impairment. It just appears from the group comparisons (1) that the dyslexics' corpus callosum displays a more circular and evenly thicker general shape, and (2) that the midsagittal surface is on the average larger than in controls, in particular in the isthmus. Moreover, the different morphometric characteristics of the dyslexic brain correlated with the degree of impairment on various tests exploring phonological abilities. In vivo morphometry of the corpus callosum may provide valuable hints for understanding developmental learning disorders and their consequences in adults.
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