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  • Title: Inhibition of lactogenic activities of bovine mammary gland explants by the whey fraction of bovine milk.
    Author: Shamay A, Shinder DA, Bruckental I, Silanikove N.
    Journal: Cell Biol Int; 1997 Sep; 21(9):601-4. PubMed ID: 9570895.
    Abstract:
    The regulation of milk constituents, synthesis and secretion in tissue cultures of the bovine mammary gland was altered by a whey fraction of bovine milk. alpha-Casein gene expression, casein secretion and fatty acid synthesis were inhibited by the whey fraction in a dose-dependent manner. The whey fraction inhibited the enhancement activity of prolactin on alpha-casein gene expression and fatty acid synthesis, and also inhibited casein secretion to the medium, in explants cultured in a medium with or without prolactin. No effect on the expression of the beta-lactoglobulin gene was found.
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