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  • Title: Calcium modulated signaling site in type 2 rod outer segment membrane guanylate cyclase (ROS-GC2).
    Author: Goraczniak RM, Duda T, Sharma RK.
    Journal: Biochem Biophys Res Commun; 1998 Apr 17; 245(2):447-53. PubMed ID: 9571173.
    Abstract:
    The ROS-GC subfamily of membrane guanylate cyclases is at present represented by two members: ROS-GC1 and ROS-GC2. A unique functional feature of this subfamily is that it is intracellularly modulated in low Ca2+ concentration by calmodulin-like Ca(2+)-binding proteins termed GCAPs, 1 and 2, and the modulation is consistent with its linkage to phototransduction. The present study shows that: (1) GCAP2 is a specific modulator of ROS-GC2; (2) through systematic remodeling of ROS-GC modules, the study also shows that the modulated domain resides within the amino acid segment 736-1020. This domain is distinct form the corresponding GCAP1-modulated ROS-GC1 domain. Thus, GCAP1 and GCAP2 act through different ROS-GCs and through two different cyclase domains.
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