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  • Title: A convenient and efficient synthesis of sialyl Lewis X.
    Author: Baba K, Iwata N, Hamajima H, Ikami T, Ishida H, Hasegawa A, Kiso M.
    Journal: Biosci Biotechnol Biochem; 1998 Mar; 62(3):590-2. PubMed ID: 9571794.
    Abstract:
    A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by using dimethyl(methylthio)sulfonium triflate (DMTST) as the promoter.
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