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  • Title: [A trial of the use of the low-molecular heparin sulodexide in the therapy of diabetic nephropathy].
    Author: Zalevskaia AG, Astamirova KhS, Karpova IA, Popova SG.
    Journal: Ter Arkh; 1998; 70(3):71-4. PubMed ID: 9575594.
    Abstract:
    AIM: Investigation of sulodexide effects on renal function, hemostasis and lipid metabolism in patients with diabetes mellitus. MATERIALS AND METHODS: 20 diabetics (diabetes mellitus type I and II) received sulodexide (Vessel due F) for 3 weeks. This mixture of low molecular heparin and dermatan sylphate was injected i.m. once a day for 5 days a week with a 2-day interval. Micro- and macro-albuminuria diminished after treatment but further returned to baseline levels. The rate of glomerular filtration, blood levels of glucose and cholesterol, hemostatic parameters remained unchanged. Blood triglycerides fell. CONCLUSION: Sulodexide may be useful in pathogenetic treatment of diabetic nephropathy.
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