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  • Title: Budd-Chiari syndrome related to factor V Leiden mutation.
    Author: Delarive J, Gonvers JJ.
    Journal: Am J Gastroenterol; 1998 Apr; 93(4):651-2. PubMed ID: 9576466.
    Abstract:
    We here describe a young patient who presented with chronic Budd-Chiari syndrome. An exhaustive etiological investigation to detect a procoagulable state was negative except for factor V mutation (factor V Leiden), a factor associated with resistance to activated protein C. Factor V Leiden is known to be a common, high risk factor for thrombosis. This factor should be routinely investigated in patients with Budd-Chiari syndrome, as factor V Leiden mutation is probably the procoagulable state responsible for many cases of "idiopathic" Budd-Chiari syndrome.
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