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  • Title: [Polyclonal plasmacytosis in peripheral blood and leukocytoclastic vasculitis in Castleman's disease].
    Author: Izutsu K, Usuki K, Inoue K, Endo M, Iki S, Matsuya S, Urabe A.
    Journal: Rinsho Ketsueki; 1998 Mar; 39(3):210-5. PubMed ID: 9577645.
    Abstract:
    A 62 year-old man had fever, splenomegaly, systemic lymphadenopathy and palpable petechiae. Laboratory studies showed leukocytosis (10,200/microliters) with plasma cells (23%) and polyclonal gammopathy. Southern blot analysis of peripheral blood mononuclear cells showed no rearrangement of immunoglobulin genes, indicating polyclonal plasmacytosis in peripheral blood. A diagnosis of Castleman's disease was made by the cervical lymph node biopsy, which showed onion-skin structures in the germinal centers and plasmacytosis in the interfollicular region. A skin biopsy of the purpura lesion disclosed leukocytoclastic vasculitis. This is an unusual case of Castleman's disease presenting plasmacytosis in peripheral blood and leukocytoclastic vasculitis.
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