These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Acute promyelocytic leukemia relapse as leukemia cutis shortly after complete remission with all-trans retinoic acid].
    Author: Itoh K, Gotoh W, Yagasaki F, Itoh Y, Kawai N, Matsuda A, Tominaga K, Kusumoto S, Ino H, Murohashi I, Jinnai I, Takeuchi H, Bessho M, Hirashima K.
    Journal: Rinsho Ketsueki; 1998 Mar; 39(3):221-6. PubMed ID: 9577647.
    Abstract:
    A 56-year-old man was admitted to our hospital in September, 1996. Chromosomal translocation (15; 17) and a PT-PCR study for PML-RAR alpha mRNA were positive in bone marrow aspirates, and acute promyelocytic leukemia was diagnosed. After CR was obtained with all-trans retinoic acid (ATRA) followed up with chemotherapy, the RT-PCR became negative. When he was readmitted in April, 1997, skin eruption on his chest and extremities were observed. Specimens taken for biopsy revealed leukemia cutis, and RT-PCR became positive in the same specimen. Bone marrow PT-PCR was also positive without abnormal promyelocytes. Although he was treated with oral ATRA 80 mg/day again, no significant improvement in leukemia cutis was noted. After combined therapy with Ara-C and acularubicin, skin eruption disappeared and bone marrow RT-PCR became negative. A second CR was then obtained. Although it is unknown whether the administration of ATRA is related to extramedullary relapse or not, we recommend combined chemotherapy for such cases.
    [Abstract] [Full Text] [Related] [New Search]