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  • Title: The ability of human polymorphonuclear cells (PMNS) to release of soluble IL-6 receptor (IL-6sR) in response to different stimuli in vitro.
    Author: Jabłońska E, Pietruska Z.
    Journal: Rocz Akad Med Bialymst; 1997; 42(1):89-98. PubMed ID: 9581468.
    Abstract:
    In the present work we have examined the release of soluble IL-6 receptor (IL-6sR) by polymorphonuclear cells (PMNs) in response to different stimuli: zymosan, ConA, PHA and LPS. We have also investigated the generation of IL-6sR by whole blood cells (WBC) under the same condition of the culture. IL-6sR secreted by PMNs and WBC were detected in cell-free supernatants by ELISA. Results of our investigation revealed that freshly isolated PMNs from healthy subjects exhibit a different ability to the secretion of IL-6sR in response to used stimuli. LPS showed the most significant effect on the IL-6sR secretion by PMNs and WBC as compared to the other inducers. The mean concentrations of IL-6sR released by PMNs were lower than concentrations of IL-6sR released by WBC. Measurements of the IL-6sR secretion by immunocompetent cells appear to be useful in the estimation of the cellular activity mediated by IL-6.
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