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  • Title: Influence of endotoxin on the level of tumor necrosis factor alfa and blood morphology in rats.
    Author: Hryniewicz A, Kozłowska H, Hołownia E, Kemona A, Poczopko B, Dziecioł J, Puch U.
    Journal: Rocz Akad Med Bialymst; 1997; 42(1):267-76. PubMed ID: 9581491.
    Abstract:
    The influence of endotoxin E.coli O127 B:8 given intravenously or intraperitoneally on the level of Tumor Necrosis Factor alfa (TNF-alpha), blood cells count and bone marrow morphology in rats was studied. The presented results show that endotoxin (3 mg/kg) given intravenously or intraperitoneally (1 or 3 times) provoked an appearance of TNF-alpha in the systemic circulation 24 hours after its injection. Endotoxin given intravenously evoked greater changes in blood morphology and bone marrow than that applicated intraperitoneally.
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