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  • Title: Localized mutagenesis in Streptomyces coelicolor A3 (2).
    Author: Randazzo R, Sciandrello G, Carere A, Bignami M, Velcich A, Sermonti G.
    Journal: Mutat Res; 1976 Sep; 36(3):291-302. PubMed ID: 958227.
    Abstract:
    Nutritional mutants (co-mutants) were scored among nitrosoguanidine-induced revertants of four mutations in Streptomyces coelicolor A3 (2). All co-mutations were due to mutations in genes linked to the revertant locus. The co-mutant loci were located in a region of about 20 map units around the revertant locus (co-mutation region). Revertants for different loci showed co-mutation patterns different from each other and from that of random nitrosoguanidine-induced forward mutations. Mutations appeared to be completely abolished outside the co-mutation region (mutation restriction).
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