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  • Title: [Vitamin E activity of some alpha-tocopherol derivatives and their effect on the ubiquinone level in rat liver in vitro].
    Author: Donchenko GV, Kovalenko VN, Zolotashko OM, Makovetskiĭ VP, Basalkevich ED, Sivachek TE, Svishchuk AA, Khalmuradov AG.
    Journal: Prikl Biokhim Mikrobiol; 1979; 15(1):18-23. PubMed ID: 95824.
    Abstract:
    An addition of alpha-tocopherol (I) and its synthetic derivatives (alpha-tocopheryl quinone (II), its short-chained analog (III), alpha-tocopherol lactone (IV), and short-chained alpha-tocopheryl acetate (V)) to the homogenized liver of vitamin E deficient rats resulted in a significant increase of ubiquinone after 2 hour incubation. Activity of the above derivatives (II-V) was not associated directly with their transformation into I or with a noticeable increase of the I content. There is a certain correlation between the chemical structure and the level of vitamin E activity of alpha-tocopherol derivatives that led to an increase in the ubiquinone content and prevented the decrease of tissue respiration and termination of pregnancy in rats.
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