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  • Title: [Behavior of some parameters of lipid and energy metabolism. 2. Activity of citrate synthase, ATP citrate lyase, fatty acid synthase, and glucose-6-phosphate dehydrogenase in liver of growing rats on diets differing in fat content].
    Author: Risse S, Schülke B, Dargel D, Fischer K.
    Journal: Nahrung; 1976; 20(6):613-8. PubMed ID: 958360.
    Abstract:
    In continuation of previous investigations, the authors studied the behaviour of the activities of certain enzymes (citrate synthase, adenosine triphosphate citrate lyase, fatty acid synthase and glucose-6-phosphate dehydrogenase) in the livers of growing rats on diets differing in fat content. A high-fat diet resulted in a reduction of the activities of fatty acid synthase, glucose-6-phosphate dehydrogenase and adenosine triphosphate citrate lyase, whereas the activity of citrate synthase increased, which is interpreted in the sense of an acceleration of the introduction of acetyl residues into the citrate cycle for the purpose of oxidative final degradation, and as a removal of acetyl CoA for the purpose of fatty acid synthesis.
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