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  • Title: Age-related changes in the cerebrospinal fluid level of beta-endorphin and substance P. Short communication.
    Author: Nagamitsu S, Matsuishi T, Komori H, Yamashita Y, Eguchi H, Ichikawa K, Fujimoto T, Kato H.
    Journal: J Neural Transm (Vienna); 1998; 105(1):53-8. PubMed ID: 9588760.
    Abstract:
    To evaluate the early age-related changes in neuropeptides, we have measured the cerebrospinal fluid (CSF) levels of beta-endorphin and substance P in young patients over a range of ages. Specimens of CSF were obtained from 39 neurologically normal children, aged 1 month to 10 years of age, and in 9 adult controls. CSF levels of both neuropeptides were observed to peak during the first year of life, and showed a negative correlation with increasing age. A significant positive correlation was observed between the CSF level of beta-endorphin and that of substance P.
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