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  • Title: HPLC-fluorescence determination of chlorocresol and chloroxylenol in pharmaceuticals.
    Author: Gatti R, Roveri P, Bonazzi D, Cavrini V.
    Journal: J Pharm Biomed Anal; 1997 Nov; 16(3):405-12. PubMed ID: 9589397.
    Abstract:
    The use of 2-chloro-6,7-dimethoxy-3-quinolinecarboxaldehyde as a fluorogenic labelling reagent in pre-column derivatization for the HPLC separation of chlorophenols has been investigated. The compound reacts (50 min at 110 degrees C) with 2- and 4-chlorophenols to give fluorescent ethers that can be separated by reversed-phase HPLC and detected at lambda exc = 360 nm, lambda em = 500 nm. The experimental conditions for derivatization and chromatographic separation are discussed. Applications for the determination of chlorocresol (4-chloro-3-cresol) and chloroxylenol (4-chloro-3,5-xylenol) in pharmaceutical formulations (creams, ointments) are described.
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