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  • Title: Detection of circulating tumor cells in a patient with intravascular lymphomatosis: a case study examined by the cytology method.
    Author: Emura I, Naito M, Wakabayashi M, Yoshizawa H, Arakawa M, Chou T.
    Journal: Pathol Int; 1998 Jan; 48(1):63-6. PubMed ID: 9589467.
    Abstract:
    Detection of circulating tumor cells in a patient with intravascular lymphomatosis (IVL) of the lung is reported. Peripheral blood cells were suspended in an isotonic sodium chloride solution, and red blood cells were lysed. The suspension was smeared on glass slides, fixed in 95% ethanol solution and stained using the Papanicolaou method. At the diagnosis of IVL, approximately 65 tumor cells were detected in one smear preparation, which contained about 8 x 10(5) nucleated cells. However, tumor cells disappeared from peripheral blood when those in the lung were eliminated by multiagent chemotherapy. Cytology examination of peripheral blood cells may be of assistance in the early diagnosis of IVL and in the assessment of therapeutic intervention.
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