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  • Title: Combination antifungal therapy for cryptococcal meningitis.
    Author: Tobias JS, Wrigley PF, Shaw E.
    Journal: Postgrad Med J; 1976 May; 52(607):305-8. PubMed ID: 959108.
    Abstract:
    Two patients with Hodgkin's disease and cryptococcal meningitis are described. Both patients were treated with a combination of the two antifungal agents, amphotericin B and flucytosine. Nephrotoxicity was easily reversible in both patients and clinical improvement was seen with this combination therapy. Intrathecal therapy with amphotericin B was used in both patients. The optimal treatment of this disease may prove to be a combination of oral flucytosine, with amphotericin B given by intrathecal injection as well as rapid low dose intravenous injection.
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