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  • Title: Technetium-99m-ECD SPECT fails to show focal hyperemia of acute herpes encephalitis.
    Author: Fazekas F, Roob G, Payer F, Kapeller P, Strasser-Fuchs S, Aigner RM.
    Journal: J Nucl Med; 1998 May; 39(5):790-2. PubMed ID: 9591576.
    Abstract:
    This is a case of herpes simplex encephalitis (HSE) examined with 99mTc-ethyl cysteinate dimer (ECD) and 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT. Static images obtained with 99mTc-ECD showed a reduced tracer uptake of the temporal lobe but focal hyperactivity using 99mTc-HMPAO. Dynamic images indicated regional increase of cerebral blood perfusion with both tracers. Technetium-99m-ECD had rapid washout from the inflamed tissue, while 99mTc-HMPAO had avid uptake. Hypofixation of 99mTc-ECD leads to failure to detect the characteristic finding of temporal lobe hyperemia in acute HSE.
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