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  • Title: Reciprocal interactions among neuropeptides and adenosine in the cardiovascular system of rats: a role of K(ATP) channels.
    Author: Sakai K, Saito K.
    Journal: Eur J Pharmacol; 1998 Mar 26; 345(3):279-84. PubMed ID: 9592027.
    Abstract:
    Possible reciprocal interactions among vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and adenosine were investigated in anesthetized rats. Changes in arterial blood pressure were taken as a parameter to evaluate the interactions. The i.v. bolus injections of VIP (0.3 or 1 microg kg(-1)), CGRP (0.1 or 0.3 microg kg(-1)) and adenosine (1-100 microg kg(-1)), like acetylcholine (0.1 microg kg(-1)), produced reductions of blood pressure, accompanied by slight changes (less than 5% except for 100 microg kg(-1) adenosine) in heart rate (HR). The vasodepressor responses to VIP and CGRP were significantly augmented by i.v. infusion of adenosine (3 microg kg(-1) min(-1)). The vasodepressor responses to adenosine and CGRP by VIP (0.03 microg kg(-1) min(-1)), and those to adenosine and VIP by CGRP (1 ng kg(-1) min(-1)) were also enhanced. The response to acetylcholine remained unchanged before and during i.v. infusion of either VIP, CGRP or adenosine. The i.v. infusion of cromakalim (0.1 microg kg(-1) min(-1)) also augmented the responses to VIP, CGRP and adenosine, but not to acetylcholine, whereas a single bolus i.v. injection of glibenclamide (20 mg kg(-1)) significantly attenuated each one of them. The present results suggest that endogenous vasodilators, such as VIP, CGRP and adenosine, reciprocally interact in the body, at least partly through ATP-sensitive K+ channels.
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