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  • Title: [The inhibitory effect of TNF-alpha on alkaline phosphatase activity of human periodontal ligament fibroblasts].
    Author: Niu Z, Shi J, Xiao M.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 1996 Jul; 31(4):217-9. PubMed ID: 9592272.
    Abstract:
    The present investigation was to identify the impact of recombinant human tumor necrosis factor-alpha (TNF-ALPHA) on alkaline phosphatase (ALP) activity of cultured human periodontal ligament fibroblasts (HPLF). It was found that, after treatment with TNF-alpha, HPLF in the experimental groups showed significantly lower ALP activity than in the blank control groups (P < 0.01). Further, the ALP activity was observed to decrease progressively with increasing TNF-alpha concentrations. These findings indicate that TNF-alpha possesses a remarkable concentration-dependent inhibitory effect on human periodontal ligament fibroblasts.
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