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  • Title: [Endothelin-1 receptors of the normal adrenal gland and adrenal tumors in human].
    Author: Tang X, Zeng Z, Zhang R.
    Journal: Zhonghua Nei Ke Za Zhi; 1996 Jul; 35(7):462-5. PubMed ID: 9592318.
    Abstract:
    Endothelin-1 (ET-1) receptors of normal adrenal gland (ADR, 6 cases), aldosterone-producing adenoma (APA, 5 cases), idiopathic hyperaldosteronism (IHA, 4 cases) and pheochromocytoma (PHE, 6 cases) in human were measured by radioligand binding assay (RBA) of receptors. Binding studies using 125I-ET-1 as a radio ligand showed the presence of a single class of high-affinity binding sites for ET-1 in all of the above tissues. The values of dissociation constant (Kd) of ET-1 for its receptor were similar in ADR, APA and IHA (28.3 +/- 2.5, 27.9 +/- 6.1, 27.7 +/- 1.9 pmol/L, respectively), but the maximal binding capacity (Bmax) of ET receptor tended to be lower in APA tissue (107.2 +/- 13.2 fmol/mg protein) in comparison with ADR (P < 0.01) and IHA (P < 0.05, 274.9 +/- 40.8, 247.0 +/- 19.8 fmol/mg protein, respectively). Both the Kd (50.8 +/- 5.1 pmol/L) and Bmax (675.3 +/- 93.7 fmol/mg protein) in PHE were higher than those in ADR (P < 0.01), APA (P < 0.01) or IHA (P < 0.05 for Kd, P < 0.01 for Bmax). Our data may suggest that there is the down-regulation for ET-1 receptor in APA and support the concept of an important role of ET-1 in the paracrine-autocrine regulation of aldosterone and catecholamine secretion in the adrenal and adrenal tumors.
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